
He also did main role in Duvvada Jagannadham (2017), in 2018 Agnyaathavaasi and Vijetha, in 2019 Saaho, in 2020 Ala Vaikunthapurramloo, Sarileru Neekevvaru and Street Dancer 3D. In 2016, he appeared in Krishna Gaadi Veera Prema Gaadha, Savithri, Sanam Teri Kasam and Wazir. He also worked in Badlapur, ABCD 2, and the Tamil film Paayum Puli. In 2015, he had larger roles in Gopala Gopala and Bhale Bhale Magadivoy. In 2013 he also worked in the Tamil and Marathi film industries. He continued to work in Hindi and Telugu, and in 2012 he had his first role in a Malayalam film Karma Yodha starring Mohanlal. In 2011, Sharma had supporting roles in Singham, Oosaravelli, starring Jr. Ya Jaane Na and appeared in Golmaal Returns and Sunday. In 2008, he made an appearance in the Bollywood film Jaane Tu.

He received a Nandi Award for his dual role of Kaiser/Ajay Shastri in Athithi.

In 2007, he had roles in the Hindi movies Dhol, Dhamaal, Black Friday, and the Telugu movies Athithi and Kanthri. Murli Sharma appeared as Captain Khan in the 2004 Bollywood movie Main Hoon Na alongside Shahrukh Khan.
